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Dual GIP / GLP-1 receptor agonistFDA-approved May 2022 (Mounjaro) · November 2023 (Zepbound)Rx · Subcutaneous injection · Once weekly

Tirzepatide
(Mounjaro, Zepbound) in Jefferson City, MO

Dr. Fahad Akhtar, M.D.
Medically reviewed by Dr. Fahad Akhtar, M.D.
Physician at g1v.me, an affiliated practice

Physicians near Jefferson City, MO from the federal NPI registry. Ask each office whether it prescribes Mounjaro or Zepbound.[9]

  • Mounjaro: FDA-approved for type 2 diabetes.
  • Zepbound: FDA-approved for chronic weight management, and obstructive sleep apnea with obesity.
city providers
18
as of today

Same molecule (tirzepatide): Mounjaro in Jefferson City, Zepbound in Jefferson City

Other GLP-1 medicines: Ozempic in Jefferson City, Wegovy in Jefferson City, Semaglutide in Jefferson City

§ 02Provider directory: Missouri
18 of 18 shown

Find a physician in Jefferson City.

Every entry comes from the federal NPI registry. Ask each office what it prescribes. We do not accept payment for placement.

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Tirzepatide by Missouri town, physicians per town
§ 03Getting Tirzepatide in Jefferson City
18 providers · Jefferson City, MO

How to get Tirzepatide in Jefferson City.

18 GLP-1 prescribers and 5 local resource types are on record for Jefferson City, plus 3 nearby towns in the directory.

Physicians in Jefferson City
18 physicians
18 physicians from the federal NPI registry in Jefferson City, most listed as Family Medicine (11), Internal Medicine, Endocrinology, Diabetes & Metabolism (4) and Internal Medicine (3). A licensed clinician who evaluates you decides whether an FDA-approved GLP-1 fits. Telehealth rules vary by state. The nearest towns on record are Columbia (29 providers), Wentzville (22 providers) and O'Fallon (5 providers).
Around the prescription in Jefferson City
5 listed nearby
12 dietitians, 6 gyms, 6 fitness clubs, 6 physiotherapists and 3 places to move are on record near Jefferson City.
Medicaid (weight loss)
Covered
As of April 2026, Missouri Medicaid covers GLP-1s for weight loss, usually with prior authorization and BMI criteria, on top of the standard diabetes coverage. Employer and private plans vary; coverage is a plan-design choice, not a state rule.

Medicaid status above is for weight-loss use and was compiled April 2026 from KFF and public Medicaid trackers; only 13 states cover it and several are mid-change, so confirm Missouri’s current Medicaid and plan rules before booking. GLPHelper provides information and provider matching, not medical or coverage advice.

§ 04Medication factsheet
cited · last review 2026.05.19

The molecule in Mounjaro and Zepbound. It acts on two gut-hormone pathways, GIP and GLP-1.

Tirzepatide is a once-weekly injection sold by Eli Lilly as Mounjaro (for type 2 diabetes) and Zepbound (for chronic weight management). It is the first approved dual GIP/GLP-1 receptor agonist. It activates two gut-hormone pathways rather than one, which is associated with greater average weight loss than single GLP-1 agonists.[2][3]

In SURMOUNT-1, adults with obesity (without diabetes) lost a mean of 20.9% of body weight on the 15 mg dose at 72 weeks, versus 3.1% on placebo. In the SURPASS-2 head-to-head diabetes trial, tirzepatide produced larger HbA1c and weight reductions than semaglutide 1 mg.[1]

Bar chart of Tirzepatide dose strengths on the FDA label: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
Tirzepatide comes in 6 strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg. The chart shows what the label lists. A prescriber sets the dose.[1]
At a glanceMultiple (brand-specific)
Active ingredient
tirzepatide
Drug class
Dual GIP / GLP-1 receptor agonist
Manufacturer
Eli Lilly
FDA approved
May 2022 (Mounjaro) · November 2023 (Zepbound)
Approved use
Type 2 diabetes (Mounjaro) · chronic weight management (Zepbound)
Off-label use
Use outside the approved brand/indication is off-label
Administration
Subcutaneous injection · Once weekly
Available doses
2.5 mg · 5 mg · 7.5 mg · 10 mg · 12.5 mg · 15 mg
Half-life
≈ 5 days
Pregnancy
Discontinue ≥ 2 months before a planned pregnancy; may reduce oral contraceptive efficacy

Community health · CDC

Weight & metabolic health in Jefferson City

Jefferson City, Missouri has a population of 43,228 people. The adult obesity rate in Jefferson City is an age-adjusted estimate of 37.4%, 2.8 percentage points above the Missouri state rate of 34.6%. Diagnosed diabetes reaches 9.8% of adults in Jefferson City. Inactivity, meaning no leisure-time physical activity reported in the past month, affects 27.1% of adults in Jefferson City.

of Jefferson City adults have obesity
37.4%
diagnosed diabetes
9.8%
no regular physical activity
27.1%

Age-adjusted estimates for Jefferson City, community figures, not individual risk. CDC PLACES, 2025 release.

Estimate your weight lossdo oral GLP-1 pills work
§ 05Support around Tirzepatide in Jefferson City
6 fitness clubs

The prescription is one part. Here is the rest, in Jefferson City.

Trials of tirzepatide paired the drug with diet counseling and regular activity. Every name below is a real listing near Jefferson City, MO, ordered as the registry lists them, never by who pays us.

Fitness clubs and recreation centers

Fitness clubs and recreation centers run classes and pools, an easier start than a weight room.

Sam B. Cook Healthplex
FITNESS
4.8 on Google · 75 reviews
1432 Southwest Blvd
Website
SOULRNR
FITNESS
5.0 on Google · 12 reviews
324 E Capitol Ave
Website
Phoenix Fitness & Athletics
FITNESS
5.0 on Google · 11 reviews
905 Eastland Dr Ste F
Website
Planet Fitness
GYM
4.8 on Google · 959 reviews
3239 Missouri Blvd
Website
Jefferson City Area YMCA - Firley Y
FITNESS
4.2 on Google · 50 reviews
525 Ellis Blvd
Website
Jefferson City Area YMCA -Knowles YMCA
FITNESS
3.9 on Google · 42 reviews
424 Stadium Blvd
Website

Registered dietitians

A registered dietitian builds the food plan around your prescription. Call to ask about GLP-1 nutrition plans and insurance.

Holly Bruemmer, RD, LD
RD
Registered dietitian
1125 Madison St
Call 573-632-5000NPI 1588238901
Rebecca Dirkes, RD
RD
Registered dietitian
635 Norris Dr
Call 406-599-6871NPI 1619695137
Sarah Eber, LD RD
RD
Registered dietitian
3400 W Truman Blvd
Call 660-349-8881NPI 1457646754
Lisa Finley, R.D., L.D
RD
Registered dietitian
1241 W Stadium Blvd
Call 573-556-5781NPI 1720173842
Heather Heberle, RD, LD
RD
Registered dietitian · Metabolic
1125 Madison
Call 573-632-5500NPI 1831341494
Rachel Hughes, RD
RD
Registered dietitian
1905 Cherry Hill Dr Ste 300
Call 573-343-4017NPI 1861104341
§ 06Clinical evidence
STEP 1 to 4 + SELECT (N = 17,604)

What the trials actually showed.

We summarize the SURMOUNT weight-management program and the SURPASS diabetes program, including the SURPASS-2 head-to-head against semaglutide. Figures are means at each trial's primary endpoint.

SURMOUNT-1 randomized 2,539 adults with obesity (without diabetes) across 72 weeks. Mean weight change was −15.0% (5 mg), −19.5% (10 mg), and −20.9% (15 mg) versus −3.1% with placebo. A majority of patients on the higher doses lost ≥20% of body weight.[2]
STEP / SELECT endpoint table2.4 mg / 68 wk
Mean weight change (15 mg)
−20.9%
SURMOUNT-1, 72 wk vs −3.1% placebo[2]
Mean weight change (5 mg)
−15.0%
SURMOUNT-1, 72 wk[2]
HbA1c reduction (T2D)
−1.8 to −2.6%
SURPASS program[4]
vs. semaglutide 1 mg
Superior
SURPASS-2, HbA1c + weight[3]
Effect size varies with baseline characteristics and adherence. Individual response may differ materially.
average tirzepatide weight loss →mapped to your starting weight
§ 07Safety & adverse events
from FDA label, sect. 6.1

Most Tirzepatide side effects are stomach and gut effects.

In Zepbound's weight trials at 5 to 15 mg, the most common side effects were nausea (25 to 29%), diarrhea (19 to 23%), constipation (11 to 17%), and vomiting (8 to 13%). Mounjaro's diabetes trials showed lower rates at the same doses.[1] Serious events were rare but include pancreatitis, gallbladder disease, and an FDA boxed warning regarding thyroid C-cell tumors based on rodent data.[1]

Boxed warning. Boxed warning: risk of thyroid C-cell tumors. Contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN-2).
Effect
Frequency
Severity
Note
Nausea
12 to 29%
mild
Lowest on Mounjaro 5 mg, highest on Zepbound 10 mg
Diarrhea
12 to 23%
mild
More frequent during dose escalation
Vomiting
5 to 13%
mild
Reduced by slower titration
Constipation
6 to 17%
mild
Decreased appetite
5 to 11%
mild
Reported in Mounjaro's diabetes trials
Pancreatitis
<0.3%
serious
Discontinue if acute pancreatitis is suspected
Gallbladder disease
~1 to 2%
serious
Cholelithiasis risk rises with rapid weight loss
Thyroid C-cell tumors
rodent data
boxed warning
Contraindicated with MTC or MEN-2 history
§ 08Cost & coverage, published, not gated
USD · monthly

What Tirzepatide costs, by how you pay.

The price you pay depends on your insurance plan, your diagnosis, and how you buy. Manufacturer self-pay programs cost far less than pharmacy retail. Here are the ranges.

Data sources: GoodRx national retail survey[6], CMS Part D formulary files[5], Eli Lilly self-pay and savings pages.

Self-pay and savings card prices checked . Retail averages from May 2026.

Tirzepatide monthly cost by how you pay
Zepbound, pharmacy retail$1,000 to $1,300per monthBrand-name retail average, May 2026[6]
Zepbound, LillyDirect self-pay$299 to $699per monthKwikPen by dose: 2.5 mg $299, 5 mg $399, 7.5 mg $499, 10 to 15 mg $699. The $449 offer on 7.5 to 15 mg applies to the first purchase and to refills within 45 days. Vials start at $299
Mounjaro, pharmacy retail$1,000 to $1,200per monthBrand-name retail average, May 2026[6]
Commercial insurance (T2D)$25 to $250per month copayUsually covered for diabetes with prior authorization
Commercial insurance (weight)Often deniedZepbound is on-label but frequently requires PA
Medicare Part D$0 to $100per monthType 2 diabetes covered. Zepbound KwikPen for weight management is $50 a month through the Medicare GLP-1 Bridge, Jul 2026 to Dec 2027[5]
Manufacturer savings cardas low as $25per monthCommercial insurance only; eligibility limits apply
Find Tirzepatide providers in Jefferson City

Physicians from the federal NPI registry. Ask each office whether it prescribes Tirzepatide.

Tirzepatide in other states

Physicians from the federal NPI registry in the states we cover. Ask each office whether it prescribes Tirzepatide.

Related GLP-1 research
§ 09Frequently asked: Tirzepatide in Missouri

The questions people ask before they book.

Answers reviewed by the glp·helper Medical Team. Citations link to primary sources, never marketing copy.

Tirzepatide is the active ingredient in two Eli Lilly brands: Mounjaro and Zepbound. No generic tirzepatide is FDA-approved in the US. Mounjaro is approved for type 2 diabetes; Zepbound is approved for chronic weight management. They share an active ingredient but carry different approved indications, and insurers treat them as separate products.[1]