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Dual GIP / GLP-1 receptor agonistFDA-approved November 2023Rx · Subcutaneous injection · Once weekly

Zepbound® providers &
prescriptions in Irvine, CA

Dr. Fahad Akhtar, M.D.
Medically reviewed by Dr. Fahad Akhtar, M.D.
Physician at g1v.me, an affiliated practice

Physicians near Irvine, CA from the federal NPI registry. Ask each office whether it prescribes Zepbound.[9]

average Zepbound weight loss →trial-anchored estimate
city providers
41
as of today

Same molecule (tirzepatide): Tirzepatide in Irvine, Mounjaro in Irvine

Other GLP-1 medicines: Ozempic in Irvine, Wegovy in Irvine, Semaglutide in Irvine

§ 02Provider directory: California
41 of 41 shown

Find a Zepbound provider in Irvine.

Every entry comes from the federal NPI registry. Ask each office what it prescribes. We do not accept payment for placement.

Filter →
Type
Provider
City
Insurance / phone
Zepbound by California town, physicians per town
§ 03Getting Zepbound in Irvine
41 providers · Irvine, CA

How to get Zepbound in Irvine.

41 GLP-1 prescribers and 7 local resource types are on record for Irvine, plus 3 nearby towns in the directory.

Physicians in Irvine
41 physicians
41 physicians from the federal NPI registry in Irvine, most listed as Internal Medicine, Endocrinology, Diabetes & Metabolism (15), Family Medicine (12) and Internal Medicine (9). A licensed clinician who evaluates you decides whether an FDA-approved GLP-1 fits. Telehealth rules vary by state. The nearest towns on record are Tustin (32 providers), Lake Forest (26 providers) and Aliso Viejo (29 providers).
Around the prescription in Irvine
7 listed nearby
104 dietitians, 23 nutritionists, 6 gyms, 6 fitness clubs, 6 trainers, 6 physiotherapists and 6 places to move are on record near Irvine.
Medicaid (weight loss)
Diabetes only
As of April 2026, California Medicaid covers GLP-1s for diabetes but not for weight loss. Employer and private plans can still cover them; that is a plan-design choice, not a state rule.

Medicaid status above is for weight-loss use and was compiled April 2026 from KFF and public Medicaid trackers; only 13 states cover it and several are mid-change, so confirm California’s current Medicaid and plan rules before booking. GLPHelper provides information and provider matching, not medical or coverage advice.

§ 04Medication factsheet
cited · last review 2026.05.19

An injectable medication for chronic weight management in adults. Same molecule as Mounjaro.

Zepbound is the brand name Eli Lilly uses for tirzepatide approved for chronic weight management. It is a once-weekly subcutaneous injection and the first approved dual GIP/GLP-1 receptor agonist. The identical molecule, marketed as Mounjaro, is the FDA-approved formulation for type 2 diabetes.[2][3]

In SURMOUNT-1, adults with obesity (without diabetes) lost a mean of 20.9% of body weight on the 15 mg dose at 72 weeks, versus 3.1% with placebo. That is among the largest average weight reductions reported for an anti-obesity medication. Zepbound is approved as an adjunct to a reduced-calorie diet and increased physical activity.[1]

Bar chart of Zepbound dose strengths on the FDA label: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
Zepbound comes in 6 strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg. The chart shows what the label lists. A prescriber sets the dose.[1]
At a glanceMultiple (per dose)
Active ingredient
tirzepatide
Drug class
Dual GIP / GLP-1 receptor agonist
Manufacturer
Eli Lilly
FDA approved
November 2023
Approved use
Chronic weight management (adults with obesity, or overweight with a weight-related condition) and moderate to severe obstructive sleep apnea in adults with obesity
Off-label use
Type 2 diabetes (Mounjaro is the FDA-approved tirzepatide for diabetes)
Administration
Subcutaneous injection · Once weekly
Available doses
2.5 mg · 5 mg · 7.5 mg · 10 mg · 12.5 mg · 15 mg
Half-life
≈ 5 days
Pregnancy
Discontinue ≥ 2 months before a planned pregnancy; may reduce oral contraceptive efficacy

Community health · CDC

Weight & metabolic health in Irvine

Irvine, California has a population of 307,670 people. The adult obesity rate in Irvine is an age-adjusted estimate of 19.5%, 9.6 percentage points below the California state rate of 29.1%. Diagnosed diabetes reaches 9% of adults in Irvine. Inactivity, meaning no leisure-time physical activity reported in the past month, affects 19.1% of adults in Irvine.

of Irvine adults have obesity
19.5%
diagnosed diabetes
9%
no regular physical activity
19.1%

Age-adjusted estimates for Irvine, community figures, not individual risk. CDC PLACES, 2025 release.

Estimate your weight losshair shedding during weight loss
§ 05Support around Zepbound in Irvine
6 gyms

The prescription is one part. Here is the rest, in Irvine.

Trials of tirzepatide paired the drug with diet counseling and regular activity. Every name below is a real listing near Irvine, CA, ordered as the registry lists them, never by who pays us.

Gyms near you

A gym gives you the regular movement that keeps muscle while the weight comes off.

24 Hour Fitness
GYM
3.9 on Google · 1,134 reviews
13692 Jamboree Rd
Website
LA Fitness
GYM
3.5 on Google · 661 reviews
3960 Barranca Pkwy
Website
SoCal Powerlifting
GYM
4.9 on Google · 401 reviews
17855 Sky Park Cir A
Website
Life Time
GYM
4.0 on Google · 323 reviews
18007 Von Karman Ave
Website
Club Studio
GYM
3.6 on Google · 231 reviews
5715 Alton Pkwy
Website
Equinox Sports Club Orange County
GYM
3.5 on Google · 221 reviews
1980 Main St
Website

Registered dietitians

A registered dietitian builds the food plan around your prescription. Call to ask about GLP-1 nutrition plans and insurance.

Gwen Adame
RD
Registered dietitian
4521 Campus Dr # 184
Call 714-644-2000NPI 1295132322
Angelica Agami, MS, BA, RD
RD
Registered dietitian
16305 Sand Canyon Ave Ste 210
Call 949-752-2227NPI 1407324064
Jensine Andrews, RDN, CLEC
RD
Registered dietitian
972 Goodrich Blvd
Call 888-499-9303NPI 1548892128
Yasaman Ansari, RDN
RD
Registered dietitian · Sports Dietetics
2108 N St Ste N
Call 949-491-3294NPI 1508227380
Shabnam Barati, RD
RD
Registered dietitian
4540 Campus Dr
Call 949-981-1120NPI 1285941856
Diane Basurto, RD
RD
Registered dietitian
19722 Macarthur Blvd
Call 949-824-9002NPI 1316501539
§ 06Clinical evidence
STEP 1 to 4 + SELECT (N = 17,604)

What the trials actually showed.

We summarize the SURMOUNT weight-management program. Figures are means at the 72-week primary endpoint, by dose.

SURMOUNT-1 randomized 2,539 adults with obesity (without diabetes) across 72 weeks. Mean weight change was −15.0% (5 mg), −19.5% (10 mg), and −20.9% (15 mg) versus −3.1% with placebo. A majority of patients on the higher doses lost ≥20% of body weight.[2]
STEP / SELECT endpoint table2.4 mg / 68 wk
Mean weight change (15 mg)
−20.9%
SURMOUNT-1, 72 wk vs −3.1% placebo[2]
Mean weight change (10 mg)
−19.5%
SURMOUNT-1, 72 wk[2]
Mean weight change (5 mg)
−15.0%
SURMOUNT-1, 72 wk[2]
Effect size varies with baseline characteristics and adherence. Individual response may differ materially.
average Zepbound weight loss →mapped to your starting weight
§ 07Safety & adverse events
from FDA label, sect. 6.1

Most Zepbound side effects are stomach and gut effects.

In Zepbound's weight trials at 5 to 15 mg, the most common side effects were nausea (25 to 29%), diarrhea (19 to 23%), constipation (11 to 17%), and vomiting (8 to 13%). Most reports came during dose escalation and decreased over time.[1] Serious events were rare but include pancreatitis, gallbladder disease, and an FDA boxed warning regarding thyroid C-cell tumors based on rodent data.[1]

Boxed warning. Boxed warning: risk of thyroid C-cell tumors. Contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN-2).
Effect
Frequency
Severity
Note
Nausea
25 to 29%
mild
Most reports came during dose escalation and decreased over time
Diarrhea
19 to 23%
mild
More frequent during dose escalation
Vomiting
8 to 13%
mild
Reduced by slower titration
Constipation
11 to 17%
mild
Abdominal pain
9 to 10%
moderate
Pancreatitis
<0.3%
serious
Discontinue if acute pancreatitis is suspected
Gallbladder disease
~1 to 2%
serious
Cholelithiasis risk rises with rapid weight loss
Thyroid C-cell tumors
rodent data
boxed warning
Contraindicated with MTC or MEN-2 history
§ 08Cost & coverage, published, not gated
USD · monthly

What Zepbound costs, by how you pay.

The price you pay depends on your insurance plan, your diagnosis, and how you buy. Manufacturer self-pay programs cost far less than pharmacy retail. Here are the ranges.

Data sources: GoodRx national retail survey[6], CMS Part D formulary files[5], Eli Lilly self-pay and savings pages.

Self-pay and savings card prices checked . Retail averages from May 2026.

Zepbound monthly cost by how you pay
Pharmacy retail (no insurance)$1,000 to $1,300per monthBrand-name retail average, May 2026[6]
LillyDirect self-pay, KwikPen or vial$299 to $699per monthKwikPen by dose: 2.5 mg $299, 5 mg $399, 7.5 mg $499, 10 to 15 mg $699. The $449 offer on 7.5 to 15 mg applies to the first purchase and to refills within 45 days. Vials start at $299
Commercial insurance (weight)Often deniedOn-label for obesity but frequently requires prior authorization
Medicare GLP-1 Bridge$50per monthKwikPen only, Jul 1, 2026 to Dec 31, 2027, Part D enrollees who meet weight and health criteria[5]
Manufacturer savings cardas low as $25per monthCommercial insurance with coverage only; eligibility limits apply
Find Zepbound providers in Irvine

Physicians from the federal NPI registry. Ask each office whether it prescribes Zepbound.

Zepbound in other states

Physicians from the federal NPI registry in the states we cover. Ask each office whether it prescribes Zepbound.

Related GLP-1 research
§ 09Frequently asked: Zepbound in California

The questions people ask before they book.

Answers reviewed by the glp·helper Medical Team. Citations link to primary sources, never marketing copy.

Zepbound and Mounjaro are both tirzepatide, made by Eli Lilly, but they carry different FDA-approved indications. Zepbound is approved for chronic weight management; Mounjaro is approved for type 2 diabetes. Insurers treat them as separate products, and weight-loss coverage is far more restricted than diabetes coverage.[1]